What is a notable symptom of porphyries?

Sensitivity to light is a notable symptom of porphyrias, which are a group of disorders caused by an overproduction of porphyrins or porphyrin precursors due to enzyme deficiencies in the heme production pathway. Individuals with certain types of porphyria, particularly erythropoietic protoporphyria and porphyria cutanea tarda, experience skin manifestations when exposed to sunlight. This sensitivity can lead to painful skin reactions, rashes, and sometimes scarring, as their skin becomes damaged more easily from UV exposure.

The other options may be symptoms of various other conditions but are not characteristic of porphyrias. Sensitivity to light is specifically associated with the unique biochemical disruptions in porphyric disorders, making it the most relevant and notable symptom in this context.